A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies.
نویسندگان
چکیده
A squaramide ester derivative of desferrioxamine B (H3DFO) that is compatible with aqueous solvents and does not induce antibody aggregation is used to attach the siderophore to the antibody trastuzumab. The new conjugates were radiolabeled with zirconium-89 to give complexes that are more resistant to ligand exchange when compared to currently used H3DFO derivatives and result in high quality positron emission tomography images in mouse models of HER2 positive breast cancer.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 77 شماره
صفحات -
تاریخ انتشار 2016